Clinicopathological characteristics of immunoglobulin G4-related sialadenitis
نویسندگان
چکیده
منابع مشابه
Clinicopathological characteristics of immunoglobulin G4-related sialadenitis
INTRODUCTION Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibro-inflammatory condition. Forty-two cases with immunoglobulin G4-related sialadenitis (IgG4-RS) confirmed by histopathological and immunohistochemical assessment were studied to clarify the clinicopathologic characteristics of the salivary glands involved in IgG4-RS, especially the relationship between the histop...
متن کاملClinicopathology of Immunoglobulin G4-Related Chronic Sclerosing Sialadenitis: A Single-Center Study.
OBJECTIVES To investigate the clinicopathologic characteristics of patients with immunoglobulin G4-related chronic sclerosing sialadenitis (IgG4-RCSS), a recently recognized disease. STUDY DESIGN Case series with chart review and pathology study. SETTINGS Tertiary care hospital. SUBJECTS AND METHODS We evaluated chronic sialadenitis specimens obtained over 11 years using pathologic examin...
متن کاملTreatment of immunoglobulin G4-related sialadenitis: outcomes of glucocorticoid therapy combined with steroid-sparing agents
BACKGROUND Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated systemic disease. Despite its good response to steroid therapy, its treatment protocol is not standardized and the long-term outcome is controversial. The study was conducted to determine the short-term and long-term outcomes of IgG4-RS patients treated with glucocorticoids and steroid-sparing immu...
متن کاملInterleukin 13-positive mast cells are increased in immunoglobulin G4-related sialadenitis
Interleukin (IL)-13 is a T helper 2 (Th2) cytokine that plays important roles in the pathogenesis of asthma. IL-13 induces hypersensitivity of the airways, increased mucous production, elevated serum immunoglobulin (Ig) E levels, and increased numbers of eosinophils. Many patients with IgG4-related disease have allergic backgrounds and show elevated serum IgE levels and an increase in the numbe...
متن کاملImmunoglobulin G4 and related diseases.
i mmunoglobulins, produced by plasma cells, are the effector arm of the humoral immune system [1]. Each immunoglobulin consists of two identical heavy chains (α, β, γ, δ or ε – all encoded by chromosome 14) and two identical light chains (either κ or λ, encoded by chromosome 2 and 22, respectively) [2]. The immunoglobulins have constant (C) regions (similar within the same isotype) and variable...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2015
ISSN: 1478-6354
DOI: 10.1186/s13075-015-0698-y